Ontology highlight
ABSTRACT:
SUBMITTER: Bonekamp NA
PROVIDER: S-EPMC8408345 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Bonekamp Nina A NA Jiang Min M Motori Elisa E Garcia Villegas Rodolfo R Koolmeister Camilla C Atanassov Ilian I Mesaros Andrea A Park Chan Bae CB Larsson Nils-Göran NG
Life science alliance 20210830 11
Mitochondrial transcription factor A (TFAM) is compacting mitochondrial DNA (dmtDNA) into nucleoids and directly controls mtDNA copy number. Here, we show that the TFAM-to-mtDNA ratio is critical for maintaining normal mtDNA expression in different mouse tissues. Moderately increased TFAM protein levels increase mtDNA copy number but a normal TFAM-to-mtDNA ratio is maintained resulting in unaltered mtDNA expression and normal whole animal metabolism. Mice ubiquitously expressing very high TFAM l ...[more]