Multifunctional protein 4.1R regulates the asymmetric segregation of Numb during terminal erythroid maturation.

ABSTRACT: The asymmetric cell division of stem or progenitor cells generates daughter cells with distinct fates that balance proliferation and differentiation. Asymmetric segregation of Notch signaling regulatory protein Numb plays a crucial role in cell diversification. However, the molecular mechanism remains unclear. Here, we examined the unequal distribution of Numb in the daughter cells of murine erythroleukemia cells (MELCs) that undergo DMSO-induced erythroid differentiation. In contrast to the cytoplasmic localization of Numb during uninduced cell division, Numb is concentrated at the cell boundary in interphase, near the one-spindle pole in metaphase, and is unequally distributed to one daughter cell in anaphase in induced cells. The inheritance of Numb guides this daughter cell toward eryt

SUBMITTER: Huang SC 

PROVIDER: S-EPMC8408529 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature