Association of Matrix Metalloproteinase-1 Genotypes With Bladder Cancer Risk.

ABSTRACT:

Aim

There is very little literature reporting the association of matrix metalloproteinase-1 (MMP1) with personal susceptibility to bladder cancer. In the current study, we carried out the first examination of the contribution of MMP1 rs1799750 to bladder cancer risk in Taiwanese.

Materials and methods

A total of 375 bladder cancer cases and 375 healthy controls were genotyped for MMP1 rs1799750 via polymerase chain reaction-restriction fragment length polymorphism methodology and this was evaluated for association with clinicopathological factors.

Results

The frequencies of MMP1 rs1799750 2G/2G, 1G/2G, and 1G/1G genotypes were 35.7%, 44.8% and 19.5% in the group with bladder cancer and 32.5%, 46.4%, and 21.1% in the healthy control group (p for trend=0.6362). The odds

SUBMITTER: Liao CH 

PROVIDER: S-EPMC8408719 | biostudies-literature | 2021 Sep-Oct

REPOSITORIES: biostudies-literature