Influenza Vaccine Effectiveness Against Hospitalization in the United States, 2019-2020.

ABSTRACT:

Background

Influenza causes significant morbidity and mortality and stresses hospital resources during periods of increased circulation. We evaluated the effectiveness of the 2019-2020 influenza vaccine against influenza-associated hospitalization in the United States.

Methods

We included adults hospitalized with acute respiratory illness at 14 hospitals and tested for influenza viruses by reserve-transcription polymerase chain reaction. Vaccine effectiveness (VE) was estimated by comparing the odds of current-season influenza vaccination in test-positive influenza cases vs test-negative controls, adjusting for confounders. VE was stratified by age and major circulating influenza types along with A(H1N1)pdm09 genetic subgroups.

Results

A total of 3116 participants wer

SUBMITTER: Tenforde MW 

PROVIDER: S-EPMC8408767 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature