Ontology highlight
ABSTRACT:
SUBMITTER: Abdelnabi R
PROVIDER: S-EPMC8408768 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Abdelnabi Rana R Foo Caroline S CS De Jonghe Steven S Maes Piet P Weynand Birgit B Neyts Johan J
The Journal of infectious diseases 20210901 5
The emergence of SARS-CoV-2 variants of concern (VoCs) has exacerbated the COVID-19 pandemic. Currently available monoclonal antibodies and vaccines appear to have reduced efficacy against some of these VoCs. Antivirals targeting conserved proteins of SARS-CoV-2 are unlikely to be affected by mutations arising in VoCs and should therefore be effective against emerging variants. We here investigate the efficacy of molnupiravir, currently in phase 2 clinical trials, in hamsters infected with Wuhan ...[more]