Selective and Improved Photoannealing of Microporous Annealed Particle (MAP) Scaffolds.

ABSTRACT: Microporous annealed particle (MAP) scaffolds consist of a slurry of hydrogel microspheres that undergo annealing to form a solid scaffold. MAP scaffolds have contained functional groups with dual abilities to participate in Michael-type addition (gelation) and radical polymerization (photoannealing). Functional groups with efficient Michael-type additions react with thiols and amines under physiological conditions, limiting usage for therapeutic delivery. We present a heterofunctional maleimide/methacrylamide 4-arm PEG macromer (MethMal) engineered for selective photopolymerization compatible with multiple polymer backbones. Rheology using two classes of photoinitiators demonstrates advantageous photopolymerization capabilities. Functional assays show benefits for therapeutic delivery and

SUBMITTER: Pfaff BN 

PROVIDER: S-EPMC8408836 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature