Meal-induced inflammation: postprandial insights from the Personalised REsponses to DIetary Composition Trial (PREDICT) study in 1000 participants.

ABSTRACT:

Background

Meal-induced metabolic changes trigger an acute inflammatory response, contributing to chronic inflammation and associated diseases.

Objectives

We aimed to characterize variability in postprandial inflammatory responses using traditional (IL-6) and novel [glycoprotein acetylation (GlycA)] biomarkers of inflammation and dissect their biological determinants with a focus on postprandial glycemia and lipemia.

Methods

Postprandial (0-6 h) glucose, triglyceride (TG), IL-6, and GlycA responses were measured at multiple intervals after sequential mixed-nutrient meals (0 h and 4 h) in 1002 healthy adults aged 18-65 y from the PREDICT (Personalised REsponses to DIetary Composition Trial) 1 study, a single-arm dietary intervention study. Measures of habitual diet, bl

SUBMITTER: Mazidi M 

PROVIDER: S-EPMC8408875 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature