A meta-analysis of observational studies on anticholinergic burden and fracture risk: evaluation of conventional burden scales.

ABSTRACT:

Background

Anticholinergic burden potentially increases the risk of fracture. Although there are various anticholinergic burden scales, little is known about the inter-scale compatibility regarding the relationship of anticholinergic burden with fracture risk. We performed meta-analysis to examine the association of fracture risk with anticholinergic burden measured using various scales.

Methods

Primary literature was retrieved from PubMed (1966 to March, 2021), the Cochrane Library (1974 to March, 2021), Scopus (1970 to March, 2021), and Ichushi-web (1983 to March, 2021). Cohort and case-control studies that evaluated the association between any fracture and anticholinergic drugs were included. Additionally, we included studies in which patients were administered anticholin

SUBMITTER: Ogawa Y 

PROVIDER: S-EPMC8408921 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature