Stability of clonidine hydrochloride in an oral powder form compounded for pediatric patients in Japan.

ABSTRACT:

Background

Clonidine hydrochloride is used to treat sedative agent withdrawals, malignant hypertension, and anesthesia complications. Clonidine is also prescribed off-label to pediatric patients at a dose of 1 μg/kg. The commercially available enteral form of clonidine, Catapres® tablets, is often compounded into a powder form by pharmacists to achieve dosage adjustments for administration to pediatric patients. However, the stability and quality of compounded clonidine powder have not been verified. The objectives of this study were to formulate a 0.2 mg/g oral clonidine hydrochloride powder and assess the stability and physical properties of this compounded product in storage.

Methods

A 0.2 mg/g clonidine powder was prepared by adding lactose monohydrate to crushed and fil

SUBMITTER: Saito J 

PROVIDER: S-EPMC8408926 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature