HOX cluster and their cofactors showed an altered expression pattern in eutopic and ectopic endometriosis tissues.

ABSTRACT: Endometriosis is major gynecological disease that affects over 10% of women worldwide and 30%-50% of these women have pelvic pain, abnormal uterine bleeding and infertility. The cause of endometriosis is unknown and there is no definite cure mainly because of our limited knowledge about its pathophysiology at the cellular and molecular levels. Therefore, demystifying the molecular mechanisms that underlie endometriosis is essential to develop advanced therapies for this disease. In this regard, HOX genes are remarkable because of their critical role in endometrial development and receptivity during implantation, which is attributed to their ability to mediate some of the sex steroid functions during the reproductive period. Access to the expression profiles of these genes would provide the

SUBMITTER: Esfandiari F 

PROVIDER: S-EPMC8409001 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature