Exposure to Perfluoroalkyl Substances and Glucose Homeostasis in Youth.

ABSTRACT:

Background

Exposure to per- and polyfluoroalkyl substances (PFAS), a prevalent class of persistent pollutants, may increase the risk of type 2 diabetes.

Objective

We examined associations between PFAS exposure and glucose metabolism in youth.

Methods

Overweight/obese adolescents from the Study of Latino Adolescents at Risk of Type 2 Diabetes (SOLAR; n=310) participated in annual visits for an average of 3.3±2.9y. Generalizability of findings were tested in young adults from the Southern California Children's Health Study (CHS; n=135) who participated in a clinical visit with a similar protocol. At each visit, oral glucose tolerance tests were performed to estimate glucose metabolism and β-cell function via the insulinogenic index. Four PFAS were measured at baseline u

SUBMITTER: Goodrich JA 

PROVIDER: S-EPMC8409228 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature