Ontology highlight
ABSTRACT:
SUBMITTER: Kikushige Y
PROVIDER: S-EPMC8409405 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Cancer science 20210714 9
Acute myeloid leukemia (AML) is hierarchically organized by self-renewing leukemic stem cells (LSCs). LSCs originate from hematopoietic stem cells (HSCs) by acquiring multistep leukemogenic events. To specifically eradicate LSCs, while keeping normal HSCs intact, the discrimination of LSCs from HSCs is important. We have identified T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) as an LSC-specific surface molecule in human myeloid malignancies and demonstrated its essential function ...[more]