A comparison of cognitive performance in the Suffolk County cohort and their unaffected siblings.

ABSTRACT: People diagnosed with schizophrenia and other psychoses demonstrate impaired neuropsychological performance. Their unaffected siblings exhibit mild impairments relative to unrelated controls, suggesting genetic and shared environmental risk for psychosis account for some portion of cognitive impairments observed in cases. However, most sibling studies were conducted early in illness course. Studying cases and unaffected siblings later in life is valuable because diagnostic misclassification is common early in illness, possibly leading to spurious conclusions. This study compared neuropsychological performance of individuals with psychotic disorders (schizophrenia and other psychoses), their unaffected siblings, and controls. Assessments were conducted 20 years after case enrollment in the

SUBMITTER: Valerio KE 

PROVIDER: S-EPMC8409437 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature