Genome-scale sequencing and analysis of human, wolf, and bison DNA from 25,000-year-old sediment.

ABSTRACT: Cave sediments have been shown to preserve ancient DNA but so far have not yielded the genome-scale information of skeletal remains. We retrieved and analyzed human and mammalian nuclear and mitochondrial environmental "shotgun" genomes from a single 25,000-year-old Upper Paleolithic sediment sample from Satsurblia cave, western Georgia:first, a human environmental genome with substantial basal Eurasian ancestry, which was an ancestral component of the majority of post-Ice Age people in the Near East, North Africa, and parts of Europe; second, a wolf environmental genome that is basal to extant Eurasian wolves and dogs and represents a previously unknown, likely extinct, Caucasian lineage; and third, a European bison environmental genome that is basal to present-day populations, suggesting

SUBMITTER: Gelabert P 

PROVIDER: S-EPMC8409484 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature