Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response.

ABSTRACT: Macroautophagy (hereafter autophagy) degrades and recycles intracellular components to sustain metabolism and survival during starvation. Host autophagy promotes tumor growth by providing essential tumor nutrients. Autophagy also regulates immune cell homeostasis and function and suppresses inflammation. Although host autophagy does not promote a T-cell anti-tumor immune response in tumors with low tumor mutational burden (TMB), whether this was the case in tumors with high TMB was not known. Here we show that autophagy, especially in the liver, promotes tumor immune tolerance by enabling regulatory T-cell function and limiting stimulator of interferon genes, T-cell response and interferon-γ, which enables growth of high-TMB tumors. We have designated this as hepatic autophagy immune toler

SUBMITTER: Poillet-Perez L 

PROVIDER: S-EPMC8409526 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature