Ontology highlight
ABSTRACT:
SUBMITTER: Heishima K
PROVIDER: S-EPMC8409585 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Heishima Kazuki K Sugito Nobuhiko N Soga Tomoyoshi T Nishikawa Masashi M Ito Yuko Y Honda Ryo R Kuranaga Yuki Y Sakai Hiroki H Ito Ryo R Nakagawa Takayuki T Ueda Hiroshi H Akao Yukihiro Y
The Journal of clinical investigation 20210901 17
Mitochondrial electron transport chain complex I (ETCC1) is the essential core of cancer metabolism, yet potent ETCC1 inhibitors capable of safely suppressing tumor growth and metastasis in vivo are limited. From a plant extract screening, we identified petasin (PT) as a highly potent ETCC1 inhibitor with a chemical structure distinct from conventional inhibitors. PT had at least 1700 times higher activity than that of metformin or phenformin and induced cytotoxicity against a broad spectrum of ...[more]