NK cells eliminate Epstein-Barr virus bound to B cells through a specific antibody-mediated uptake.

ABSTRACT: Epstein Barr virus (EBV) causes a highly prevalent and lifelong infection contributing to the development of some malignancies. In addition to the key role played by T cells in controlling this pathogen, NK cells mediate cytotoxicity and IFNγ production in response to EBV-infected B cells in lytic cycle, both directly and through antibody (Ab)-dependent activation. We recently described that EBV-specific Ab-dependent NK cell interaction with viral particles (VP) bound to B cells triggered degranulation and TNFα secretion but not B cell lysis nor IFNγ production. In this report we show that NK cell activation under these conditions reduced B cell transformation by EBV. NK cells eliminated VP from the surface of B cells through a specific and active process which required tyrosine kinase act

SUBMITTER: Alari-Pahissa E 

PROVIDER: S-EPMC8409624 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature