Identification of Allobaculum mucolyticum as a novel human intestinal mucin degrader.

ABSTRACT: The human gut microbiota plays a central role in intestinal health and disease. Yet, many of its bacterial constituents are functionally still largely unexplored. A crucial prerequisite for bacterial survival and proliferation is the creation and/or exploitation of an own niche. For many bacterial species that are linked to human disease, the inner mucus layer was found to be an important niche. Allobaculum mucolyticum is a newly identified, IBD-associated species that is thought be closely associated with the host epithelium. To explore how this bacterium is able to effectively colonize this niche, we screened its genome for factors that may contribute to mucosal colonization. Up to 60 genes encoding putative Carbohydrate Active Enzymes (CAZymes) were identified in the genome of

SUBMITTER: van Muijlwijk GH 

PROVIDER: S-EPMC8409761 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature