Insulin resistance is independently associated with cardiovascular autonomic neuropathy in type 2 diabetes.

ABSTRACT:

Aims/introduction

Diabetic cardiovascular autonomic neuropathy (DCAN) seriously threatens the prognosis and quality of life of patients with type 2 diabetes mellitus, associated with increased mortality. The present study aimed to investigate the relevant risk factors of DCAN.

Materials and methods

The present study enrolled a total of 109 patients with type 2 diabetes mellitus. DCAN was defined as a score of at least 2 points in Ewing tests. The updated homeostasis model assessment of insulin resistance (HOMA2-IR) based on fasting C-peptide was calculated to reflect insulin resistance. Logistic regression analysis, interaction and stratified analyses were used to investigate the relationship between HOMA2-IR or other indicators and DCAN. Receiver operating characteristic an

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8409868 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature