Genomic characterization of carbapenem-non-susceptible Pseudomonas aeruginosa in Singapore.

ABSTRACT: Pseudomonas aeruginosa is a clinically important pathogen implicated in many hospital-acquired infections. Its propensity to acquire broad-spectrum resistance has earned the organism its status as a severe public health threat requiring urgent control measures. While whole-genome sequencing-based genomic surveillance provides a means to track antimicrobial resistance, its use in molecular epidemiological surveys of P. aeruginosa remains limited, especially in the Southeast Asian region. We sequenced the whole genomes of 222 carbapenem-non-susceptible P. aeruginosa (CNPA) isolates collected in 2006-2020 at the largest public acute care hospital in Singapore. Antimicrobial susceptibilities were determined using broth microdilution. Clonal relatedness, multi-locus sequenc

SUBMITTER: Teo JQ 

PROVIDER: S-EPMC8409972 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature