Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting.

ABSTRACT:

Objective

To determine the burden of comorbidities in OA and their temporal relationships in the UK.

Methods

The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched non-OA controls from UK primary care. Controls were assigned the same index date as matched cases (date of OA diagnosis). Associations between OA and 49 individual comorbidities and multimorbidities (two or more comorbidities excluding OA) both before and after OA diagnosis were estimated, adjusting for covariates, using odds ratios (aORs) and hazard ratios (aHRs), respectively.

Results

During 1997-2017, we identified 221 807 incident OA cases and 221 807 matched controls. Of 49 comorbidities examined, 38 were associated with OA

SUBMITTER: Swain S 

PROVIDER: S-EPMC8410005 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature