Ontology highlight
ABSTRACT:
SUBMITTER: Ioannidis LJ
PROVIDER: S-EPMC8410020 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Ioannidis Lisa J LJ Pietrzak Halina M HM Ly Ann A Utami Retno As RA Eriksson Emily M EM Studniberg Stephanie I SI Abeysekera Waruni W Li-Wai-Suen Connie Sn CS Sheerin Dylan D Healer Julie J Puspitasari Agatha M AM Apriyanti Dwi D Coutrier Farah N FN Poespoprodjo Jeanne R JR Kenangalem Enny E Andries Benediktus B Prayoga Pak P Sariyanti Novita N Smyth Gordon K GK Trianty Leily L Cowman Alan F AF Price Ric N RN Noviyanti Rintis R Hansen Diana S DS
JCI insight 20210722 14
IFN-γ-driven responses to malaria have been shown to modulate the development and function of T follicular helper (TFH) cells and memory B cells (MBCs), with conflicting evidence of their involvement in the induction of antibody responses required to achieve clinical immunity and their association with disease outcomes. Using high-dimensional single-cell mass cytometry, we identified distinct populations of TH1-polarized CD4+ T cells and MBCs expressing the TH1-defining transcription factor T-be ...[more]