Ontology highlight
ABSTRACT:
SUBMITTER: Ruiz EJ
PROVIDER: S-EPMC8410048 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Ruiz E Josue EJ Lan Linxiang L Diefenbacher Markus Elmar ME Riising Eva Madi EM Da Costa Clive C Chakraborty Atanu A Hoeck Joerg D JD Spencer-Dene Bradley B Kelly Gavin G David Jean-Pierre JP Nye Emma E Downward Julian J Behrens Axel A
JCI insight 20210708 13
The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. To determine the requirement for c-Jun in a mouse model of K-RasG12D-induced lung adenocarcinoma, we inducibly deleted c-Jun in the adult lung. Surprisingly, we found that inactivation of c-Jun, or mutation of its JNK phosphorylation sites, actually increased lung tumor burden. Mechanistically, we found that protein levels of the Jun family member JunD wer ...[more]