Ontology highlight
ABSTRACT:
SUBMITTER: Mirzaei S
PROVIDER: S-EPMC8410400 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Mirzaei Salimeh S Ghodsi Razieh R Hadizadeh Farzin F Sahebkar Amirhossein A
BioMed research international 20210824
In this study, we aimed to develop a pharmacophore-based three-dimensional quantitative structure activity relationship (3D-QSAR) for a set including sixty-two cytotoxic quinolines (1-62) as anticancer agents with tubulin inhibitory activity. A total of 279 pharmacophore hypotheses were generated based on the survival score to build QSAR models. A six-point pharmacophore model (AAARRR.1061) was identified as the best model which consisted of three hydrogen bond acceptors (A) and three aromatic r ...[more]