Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy.

ABSTRACT:

Background

Obesity is a frequent somatic comorbidity of major depression, and it has been associated with worse clinical outcomes and brain structural abnormalities. Converging evidence suggests that electroconvulsive therapy (ECT) induces both clinical improvements and increased subcortical grey matter volume in patients with depression. However, it remains unknown whether increased body weight modulates the clinical response and structural neuroplasticity that occur with ECT.

Methods

To address this question, we conducted a longitudinal investigation of structural MRI data from the Global ECT-MRI Research Collaboration (GEMRIC) in 223 patients who were experiencing a major depressive episode (10 scanning sites). Structural MRI data were acquired before and after ECT, and w

SUBMITTER: Opel N 

PROVIDER: S-EPMC8410473 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature