Structural atrophy of the right superior frontal gyrus in adolescents with severe irritability.

ABSTRACT: Severe irritability is common in youths with psychiatric disorders and results in significant dysfunction across domains (academic, social, and familial). Prior structural MRI studies in the pediatric population demonstrated that aberrations of cortical thickness (CT) and gray matter volume (GMV) in the fronto-striatal-temporal regions which have been associated with irritability. However, the directions of the correlations between structural alteration and irritability in the individual indices were not consistent. Thus, we aim to address this by implementing comprehensive assessments of CT, GMV, and local gyrification index (LGI) simultaneously in youths with severe levels of irritability by voxel-based morphometry and surface-based morphometry. One hundred and eight adolescents (46 yout

SUBMITTER: Seok JW 

PROVIDER: S-EPMC8410540 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature