Neuroanatomical norms in the UK Biobank: The impact of allometric scaling, sex, and age.

ABSTRACT: Few neuroimaging studies are sufficiently large to adequately describe population-wide variations. This study's primary aim was to generate neuroanatomical norms and individual markers that consider age, sex, and brain size, from 629 cerebral measures in the UK Biobank (N = 40,028). The secondary aim was to examine the effects and interactions of sex, age, and brain allometry-the nonlinear scaling relationship between a region and brain size (e.g., total brain volume)-across cerebral measures. Allometry was a common property of brain volumes, thicknesses, and surface areas (83%) and was largely stable across age and sex. Sex differences occurred in 67% of cerebral measures (median |β| = .13): 37% of regions were larger in males and 30% in females. Brain measures (49%) generally decreased w

SUBMITTER: Williams CM 

PROVIDER: S-EPMC8410561 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature