CGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila.

ABSTRACT: Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that produces the second messenger cG[2'-5']pA[3'-5']p (2'3'-cGAMP) and controls activation of innate immunity in mammalian cells^1-5. Animal genomes typically encode multiple proteins with predicted homology to cGAS^6-10, but the function of these uncharacterized enzymes is unknown. Here we show that cGAS-like receptors (cGLRs) are innate immune sensors that are capable of recognizing divergent molecular patterns and catalysing synthesis of distinct nucleotide second messenger signals. Crystal structures of human and insect cGLRs reveal a nucleotidyltransferase signalling core shared with cGAS and a diversified primary ligand-binding surface modified with notable insertions and deletions. We demonstrate that surf

SUBMITTER: Slavik KM 

PROVIDER: S-EPMC8410604 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature