Defining nosocomial transmission of Escherichia coli and antimicrobial resistance genes: a genomic surveillance study.

ABSTRACT:

Background

Escherichia coli is a leading cause of bloodstream infections. Developing interventions to reduce E coli infections requires an understanding of the frequency of nosocomial transmission, but the available evidence is scarce. We aimed to detect and characterise transmission of E coli and associated plasmids in a hospital setting.

Methods

In this prospective observational cohort study, patients were admitted to two adult haematology wards at the Cambridge University Hospitals NHS Foundation Trust in England. Patients aged 16 years and older who were treated for haematological malignancies were included. Stool samples were collected from study participants on admission, once per week, and at discharge. We sequenced multiple E coli isolates

SUBMITTER: Ludden C 

PROVIDER: S-EPMC8410606 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature