Reducing Radiation Exposure to Paediatric Patients Undergoing [18F]FDG-PET/CT Imaging.

ABSTRACT:

Purpose

To investigate the possibility of reducing the injected activity for whole-body [18F]FDG-PET/CT studies of paediatric oncology patients and to assess the usefulness of time-of-flight (TOF) acquisition on PET image quality at reduced count levels.

Procedures

Twenty-nine paediatric oncology patients (12F/17M, 3-18 years old (median age 13y), weight 45±20 kg, BMI 19±4 kg/m²), who underwent routine whole-body PET/CT examinations on a Siemens Biograph mCT TrueV system with TOF capability (555ps) were included in this study. The mean injected activity was 156 ± 45 MBq (3.8 ± 0.8 kg/MBq) and scaled to patient weight. The raw data was collected in listmode (LM) format and pre-processed to simulate reduced levels of [18F]FDG activity (75, 50, 35, 20 and 10% of the

SUBMITTER: Kertesz H 

PROVIDER: S-EPMC8410733 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature