Olfactory bulb astrocytes mediate sensory circuit processing through Sox9 in the mouse brain.

ABSTRACT: The role of transcription factors during astrocyte development and their subsequent effects on neuronal development has been well studied. Less is known about astrocytes contributions towards circuits and behavior in the adult brain. Astrocytes play important roles in synaptic development and modulation, however their contributions towards neuronal sensory function and maintenance of neuronal circuit architecture remain unclear. Here, we show that loss of the transcription factor Sox9 results in both anatomical and functional changes in adult mouse olfactory bulb (OB) astrocytes, affecting sensory processing. Indeed, astrocyte-specific deletion of Sox9 in the OB results in decreased odor detection thresholds and discrimination and it is associated with aberrant neuronal sensory response ma

SUBMITTER: Ung K 

PROVIDER: S-EPMC8410770 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature