Maternal 17q21 genotype influences prenatal vitamin D effects on offspring asthma/recurrent wheeze.

ABSTRACT:

Background

Prenatal vitamin D₃ supplementation has been linked to reduced risk of early-life asthma/recurrent wheeze. This protective effect appears to be influenced by variations in the 17q21 functional single nucleotide polymorphism rs12936231 of the child, which regulates the expression of ORMDL3 (ORM1-like 3) and for which the high-risk CC genotype is associated with early-onset asthma. However, this does not fully explain the differential effects of supplementation. We investigated the influence of maternal rs12936231 genotype variation on the protective effect of prenatal vitamin D₃ supplementation against offspring asthma/recurrent wheeze.

Methods

We determined the rs12936231 genotype of mother-child pairs from two randomised controlled tr

SUBMITTER: Knihtila HM 

PROVIDER: S-EPMC8410880 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature