Automated assessment of CD8⁺ T-lymphocytes and stroma fractions complement conventional staging of colorectal cancer.

ABSTRACT:

Background

Tumor development is critically dependent on the supporting stroma consisting of inflammatory cells and fibroblasts. This study intended to improve prognostic prediction for early colorectal cancer (CRC) by combined estimation of T-lymphocyte and stroma fractions with conventional markers.

Methods

In total 509 and 1041 stage II/ΙΙΙ CRC from the VICTOR and QUASAR 2 trials were included as a training set and a validation set, respectively. Intratumoral CD8⁺ T-lymphocytes and stroma were identified and quantified by machine-based learning on digital sections. The primary endpoint was to evaluate the prognostic value of the combined marker for time to recurrence (TTR).

Findings

For low-risk patients (n = 598; stage Ⅱ, and stage ΙΙΙ pT1-3 pN1 with nei

SUBMITTER: Jiang D 

PROVIDER: S-EPMC8411014 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature