OGDH is involved in sepsis induced acute lung injury through the MAPK pathway.

ABSTRACT:

Background

Acute lung injury (ALI) induced by sepsis is a common cause of death in clinical practice, and there remains a lack of clinical effective treatment. Cecal ligation and puncture (CLP) is a classic animal model of sepsis, which can induce ALI. Studies have shown that in the lung injury cell model, OGDH (oxoglutarate dehydrogenase) transcription is up-regulated, which is a potential therapeutic target for acute pneumonia. The purpose of this study was to confirm the effects of OGDH on lung injury and inflammation in animal and cell models, and to explore its mechanism.

Methods

By analyzing the GSE16650 gene set, the upregulated OGDH gene was detected in the lung injury cell model. In a sepsis animal model established by CLP and a lung injury cell model, RT-PCR, immun

SUBMITTER: Hao Y 

PROVIDER: S-EPMC8411135 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature