The forkhead box transcription factor FoxP4 regulates thermogenic programs in adipocytes.

ABSTRACT: Forkhead box transcription factors have been shown to be involved in various developmental and differentiation processes. In particular, members of the FoxP family have been previously characterized in depth for their participation in the regulation of lung and neuronal cell differentiation and T-cell development and function; however, their role in adipocyte functionality has not yet been investigated. Here, we report for the first time that Forkhead box P4 (FoxP4) is expressed at high levels in subcutaneous fat depots and mature thermogenic adipocytes. Through molecular and gene expression analyses, we revealed that FoxP4 is induced in response to thermogenic stimuli, both in vivo and in isolated cells, and is regulated directly by the heat shock factor protein 1 through a heat shock res

SUBMITTER: Perie L 

PROVIDER: S-EPMC8411233 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature