Contributions of HFE polymorphisms to brain and blood iron load, and their links to cognitive and motor function in healthy adults.

ABSTRACT:

Background

Brain iron overload is linked to brain deterioration, and cognitive and motor impairment in neurodegenerative disorders and normal aging. Mutations in the HFE gene are associated with iron dyshomeostasis and are risk factors for peripheral iron overload. However, links to brain iron load and cognition are less consistent and data are scarce.

Aims and methods

Using quantitative susceptibility mapping with magnetic resonance imaging, we investigated whether C282Y and H63D contributed to aging-related increases in brain iron load and lower cognitive and motor performance in 208 healthy individuals aged 20-79 years. We also assessed the modulatory effects of HFE mutations on associations between performance and brain iron load, as well as peripheral iron metabolism.

SUBMITTER: Kalpouzos G 

PROVIDER: S-EPMC8411306 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature