Inter-breeder differences in prepulse inhibition deficits of C57BL/6J mice in a maternal immune activation model.

ABSTRACT: Genetic and environmental factors interact with each other to influence the risk of various psychiatric diseases; however, the intensity and nature of their interactions remain to be elucidated. We established a maternal infection model using polyinosinic-polycytidylic acid (Poly(I:C)) to determine the relationship between the maternal breeding environment and behavioral changes in the offspring. We purchased pregnant C57BL/6J mice from three breeders and administered Poly(I:C) (2 mg/kg) intravenously in their tail vein on gestation day 15. The offspring were raised to 8-12 weeks old and subjected to the acoustic startle tests to compare their startle response intensity, prepulse inhibition levels, and degree of the adaptation of the startle response. No statistical interaction between Pol

SUBMITTER: Kobayashi Y 

PROVIDER: S-EPMC8411318 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature