From Screening to Treatment of Pancreatic Cancer: A Comprehensive Review.

ABSTRACT:

Introduction

Pancreatic adenocarcinoma is a devastating malignancy, associated with a grim prognosis, due to its silent presentation and lack of diagnostic tests. In addition, treatment options are limited to few agents, such as 5-FU, irinotecan, oxaliplatin, gemcitabine and nab-paclitaxel.

Methods

We performed a literature search for relevant published clinical trials, abstracts of trials in progress and ongoing or planned trials for the treatment of APC using Pubmed.com, ClinicalTrials.gov and American Society of Clinical Oncology (ASCO) abstract search as sources. We present an in-depth analysis of the phase I-III clinical trials determining the role and efficacy of different modalities. We also describe rationale for future investigation.

Discussion

Despite advanc

SUBMITTER: Saif MW 

PROVIDER: S-EPMC8411391 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature