Robust dose-painting-by-numbers vs. nonselective dose escalation for non-small cell lung cancer patients.

ABSTRACT:

Purpose

Theoretical studies have shown that dose-painting-by-numbers (DPBN) could lead to large gains in tumor control probability (TCP) compared to conventional dose distributions. However, these gains may vary considerably among patients due to (a) variations in the overall radiosensitivity of the tumor, (b) variations in the 3D distribution of intra-tumor radiosensitivity within the tumor in combination with patient anatomy, (c) uncertainties of the 3D radiosensitivity maps, (d) geometrical uncertainties, and (e) temporal changes in radiosensitivity. The goal of this study was to investigate how much of the theoretical gains of DPBN remain when accounting for these factors. DPBN was compared to both a homogeneous reference dose distribution and to nonselective dose escalation (N

SUBMITTER: Petit SF 

PROVIDER: S-EPMC8411426 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature