Adiposity and Interstitial Lung Abnormalities in Community-Dwelling Adults: The MESA Cohort Study.

ABSTRACT:

Background

Obesity is associated with restrictive ventilatory defects and a faster rate of decline in FVC. This association is not exclusively mediated by mechanical factors and may reflect direct pulmonary injury by adipose-derived mediators.

Research question

Is adipose tissue involved in the pathogenesis of interstitial lung disease (ILD)?

Study design and methods

We evaluated the association of CT measures of pericardial, abdominal visceral, and abdominal subcutaneous adipose tissue with high-attenuation areas (HAAs) and interstitial lung abnormalities (ILAs) in a large multicenter cohort study of community-dwelling adults, using multivariable-adjusted models. We secondarily evaluated the association of adipose depot size with FVC and biomarkers of obesity and inf

SUBMITTER: Anderson MR 

PROVIDER: S-EPMC8411451 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature