The role of immunogenic cell death in gastrointestinal cancer immunotherapy (Review).

ABSTRACT: Modern cancer immunotherapy techniques are aimed at enhancing the responses of the patients' immune systems to fight against the cancer. The main promising strategies include active vaccination of tumor antigens, passive vaccination with antibodies specific to cancer antigens, adoptive transfer of cancer-specific T cells and manipulation of the patient's immune response by inhibiting immune checkpoints. The application of immunogenic cell death (ICD) inducers has been proven to enhance the immunity of patients undergoing various types of immunotherapy. The dying, stressed or injured cells release or present molecules on the cell surface, which function as either adjuvants or danger signals for detection by the innate immune system. These molecules are now termed 'damage-associated molecula

SUBMITTER: Songjang W 

PROVIDER: S-EPMC8411483 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature