De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity.

ABSTRACT:

Background

Gene expression-based subtyping has the potential to form a new paradigm for stratified treatment of colorectal cancer. However, current frameworks are based on the transcriptomic profiles of primary tumors, and metastatic heterogeneity is a challenge. Here we aimed to develop a de novo metastasis-oriented framework.

Methods

In total, 829 transcriptomic profiles from patients with colorectal cancer were analyzed, including primary tumors, liver metastases, and non-malignant liver samples. High-resolution microarray gene expression profiling was performed of 283 liver metastases from 171 patients treated by hepatic resection, including multiregional and/or multi-metastatic samples from each of 47 patients. A single randomly selected liver metastasis sample from eac

SUBMITTER: Moosavi SH 

PROVIDER: S-EPMC8411513 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature