Is BRD7 associated with spermatogenesis impairment and male infertility in humans? A case-control study in a Han Chinese population.

ABSTRACT:

Background

Bromodomain-containing protein 7 (BRD7), a member of the bromodomain-containing protein family, plays important roles in chromatin modification and transcriptional regulation. A recent model of Brd7-knockout mice presented azoospermia and male infertility, implying the potential role of BRD7 in spermatogenic failure in humans. This case-control study aimed to explore the association of the BRD7 gene with spermatogenic efficiency and the risk of spermatogenic defects in humans.

Results

A total of six heterozygous variants were detected in the coding and splicing regions of the BRD7 gene in patients with azoospermia. For each of four rare variants predicted to potentially damage BRD7 function, we further identified these four variants in oligozoospermia and normozoo

SUBMITTER: He T 

PROVIDER: S-EPMC8411525 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature