Human gut-derived B. longum subsp. longum strains protect against aging in a D-galactose-induced aging mouse model.

ABSTRACT:

Background

Probiotics have been used to regulate the gut microbiota and physiology in various contexts, but their precise mechanisms of action remain unclear.

Results

By population genomic analysis of 418 Bifidobacterium longum strains, including 143 newly sequenced in this study, three geographically distinct gene pools/populations, BLAsia1, BLAsia2, and BLothers, were identified. Genes involved in cell wall biosynthesis, particularly peptidoglycan biosynthesis, varied considerably among the core genomes of the different populations, but accessory genes that contributed to the carbohydrate metabolism were significantly distinct. Although active transmission was observed inter-host, inter-country, inter-city, intra-community, and intra-family, a single B. longum clone seemed

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC8411540 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature