Insights into bioinformatic approaches for repurposing compounds as anti-viral drugs.

ABSTRACT:

Background

Drug repurposing is a cost-effective strategy to identify drugs with novel effects. We searched for drugs exhibiting inhibitory activity to Herpes Simplex virus 1 (HSV-1). Our strategy utilized gene expression data generated from HSV-1-infected cell cultures which was paired with drug effects on gene expression. Gene expression data from HSV-1 infected and uninfected neurons were analyzed using BaseSpace Correlation Engine (Illumina®). Based on the general Signature Reversing Principle (SRP), we hypothesized that the effects of candidate antiviral drugs on gene expression would be diametrically opposite (negatively correlated) to those effects induced by HSV-1 infection.

Results

We initially identified compounds capable of inducing changes in gene expression oppos

SUBMITTER: Zheng W 

PROVIDER: S-EPMC8411619 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature