Comparing the consistency of electrocardiogram interval measurements by resting ECG versus 12-lead Holter.

ABSTRACT: In clinical trials, traditionally only a limited number of 12-lead resting electrocardiograms (ECGs) can be recorded and, thus, long intervals may elapse between assessment timepoints and valuable information may be missed during times when patients' cardiac electrical activity is not being monitored. These limitations have led to the increasing use of Holter recorders which provide continuous data registrations while reducing the burden on patients and freeing up time for clinical trial staff to perform other tasks. However, there is a shortage of data comparing the two approaches. In this study, data from a randomized, double-blind, four-period, crossover thorough QT study in 40 healthy subjects were used to compare continuous 12-lead Holter recordings to standard 12-lead resting ECGs wh

SUBMITTER: Mendzelevski B 

PROVIDER: S-EPMC8411681 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature