Computational Optimization of the Size of Gold Nanorods for Single-Molecule Plasmonic Biosensors Operating in Scattering and Absorption Modes.

ABSTRACT: We present a comprehensive computational study on the optimization of the size of gold nanorods for single-molecule plasmonic sensing in terms of optical refractive index sensitivity. We construct an experimentally relevant model of single-molecule-single-nanoparticle sensor based on spherically capped gold nanorods, tip-specific functionalization and passivation layers, and biotin-streptavidin affinity system. We introduce a universal figure of merit for the sensitivity, termed contrast-to-noise ratio (CNR), which relates the change of measurable signal caused by the discrete molecule binding events to the inherent measurement noise. We investigate three distinct sensing modalities relying on direct spectral measurements, monitoring of scattering intensity at fixed wavelength and photothe

SUBMITTER: Staniszewska T 

PROVIDER: S-EPMC8411831 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature