Current concepts and molecular mechanisms in pharmacogenetics of essential hypertension.

ABSTRACT: Hypertension is a leading age-related disease in our society and if left untreated, leads to fatal cardiovascular complications. The prevalence of hypertension has increased and becomes a significant global health economic burden, particularly in lower-income societies. Many loci associated with blood pressure and hypertension have been reported by genome-wide association studies that provided potential targets for pharmacotherapy. Pharmacogenetic research had shown interindividual variations in drug efficacy, safety, and tolerability. This could be due to genetic polymorphisms in the pharmacokinetics (genes involved in a transporter, plasma protein binding, and metabolism) or pharmacodynamic pathway (receptors, ion channels, enzymes). Pharmacogenetics promises great hope toward targeted t

SUBMITTER: Rahman F 

PROVIDER: S-EPMC8411967 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature