Genome-wide gene-diet interaction analysis in the UK Biobank identifies novel effects on hemoglobin A1c.

ABSTRACT: Diet is a significant modifiable risk factor for type 2 diabetes (T2D), and its effect on disease risk is under partial genetic control. Identification of specific gene-diet interactions (GDIs) influencing risk biomarkers such as glycated hemoglobin (HbA1c) is a critical step towards precision nutrition for T2D prevention, but progress has been slow due to limitations in sample size and accuracy of dietary exposure measurement. We leveraged the large UK Biobank (UKB) cohort and a diverse group of dietary exposures, including 30 individual dietary traits and 8 empirical dietary patterns, to conduct genome-wide interaction studies in ~340 000 European-ancestry participants to identify novel GDIs influencing HbA1c. We identified five variant-dietary trait pairs reaching genome-wide significan

SUBMITTER: Westerman KE 

PROVIDER: S-EPMC8411984 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature