Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits.

ABSTRACT: TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late-onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b-/- mouse model. By using high-power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune dysfunction as potential underlying mechanisms of the Purkinje cell loss.

SUBMITTER: Rademakers R 

PROVIDER: S-EPMC8412084 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature